Two teenagers have been arrested on suspicion of murder following the death of a 17-year-old boy.
The victim was stabbed near the junction of Cossington Road and Newquay Road in the Knowle West area of Bristol shortly before midnight on Friday.
The youth was taken to Frenchay Hospital but died shortly afterwards, Avon and Somerset Police said.
Two men, aged 19 and 18, have been arrested on suspicion of murder and remain in police custody.
A force spokesman appealed for witnesses to come forward.
"We would like to hear from anyone who was in the Cossington Road and Newquay Road area of Knowle West between 10.30pm and midnight last night who may have information to help police enquiries," the spokesman said.
"At present we believe this to be an isolated incident but are providing high profile patrols in the area to provide reassurance and receive information from members of the public."