The victim, believed to be aged in his early 30s, was found in Poplar in east London shortly after 10pm on Friday and died in hospital a short time later, the Metropolitan Police said.
"Two men have been arrested on suspicion of murder," a Scotland Yard spokesman said. "They have been taken to east London police stations."
He said officers believe they know the identity of the dead man, who was found in Simpsons Road at the junction with Poplar High Street, but have yet to formally identify him.
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