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'Neurostatin' could help guard against Alzheimer's

Published 12/02/2016

It is thought the compound could have the same effect on Alzheimer's as statins on heart disease
It is thought the compound could have the same effect on Alzheimer's as statins on heart disease

Millions of people could one day be given a "neurostatin" drug to guard against the early development of Alzheimer's, new research suggests.

One drug, an anti-cancer agent called bexarotene, has already been shown to prevent early brain changes linked to the disease in laboratory tests.

Scientists are in the process of identifying others that might be more effective.

The drugs have been dubbed "neurostatins" because they could be used in the same way statins are to reduce cholesterol and curb the risk of heart disease.

In this case they would be taken as a preventative strategy to keep out the seeds of Alzheimer's, accumulating clumps of toxic protein in the brain.

Professor Michele Vendruscolo, from Cambridge University, who is leading the research, said: "This in terms of an approach for Alzheimer's disease would be the equivalent of what statins do for heart conditions.

"So you would take them well in advance of developing the condition to reduce your risk.

"The dream would be to find a compound which is cheap and safe and therefore can be given early to everybody."

He explained that Alzheimer's and other neurodegenerative disease occur in old age when natural defences that prevent the formation of protein aggregates in the brain, and help to clear them away, start to fail.

"Our idea is that we should supplement these natural defences by this chemical means," he said.

Bexarotene was the first of about a dozen potential neurostatins identified by the scientists, whose research is reported in the journal Science Advances.

Laboratory experiments showed that bexarotene delayed or completely prevented the formation of clumps of fragments of beta-amyloid protein, one of the hallmarks of Alzheimer's.

Other tests were conducted on lab worms genetically modified to develop an Alzheimer's-like condition.

"We found that when given early to the worms, bexarotene was preventing the disease," said Prof Vendruscolo. "In this worm, it was acting as a neurostatin. When given late it did nothing."

People would start taking neurostatins long before they were likely to develop symptoms of dementia, perhaps as early as their 30s.

In practice the drugs would probably be directed towards individuals most at risk. How they would be identified is not yet clear but they might include people carrying genes linked to the disease.

Science Advances is published by the American Association for the Advancement of Science, whose annual meeting is taking place in Washington DC.

Dr Rosa Sancho, chief scientist at Alzheimer's Research UK, said: "We know that the accumulation of amyloid is a hallmark feature of Alzheimer's and that drugs to halt this build-up could help protect nerve cells from damage and death.

"A recent clinical trial of bexarotene in people with Alzheimer's was not successful, but this new work in worms suggests the drug may need to be given very early in the disease.

"We will now need to see whether this new preventative approach could halt the earliest biological events in Alzheimer's and keep damage at bay in further animal and human studies."

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