Boris Johnson will come up against India's equivalent of David Letterman as he appears on one of the country's most famous current affairs programmes.
The London mayor, who will round off the tour of India to promote business links with the capital, will also visit the Bombay stock exchange before he appears on Times Now with Arnab Goswami.
Goswami is one of India's most prominent chat show hosts and has also interviewed Gordon Brown, Hillary Clinton and Sonia Gandhi.
Mr Johnson is no stranger to combative television interviews. He appeared on Letterman's Late Show in the United States in June and was asked: "And how long have you been cutting your own hair?"
Mr Johnson replied: "That's a low blow. I was beginning to think I had got through this pretty unscathed."
But Prime Minister David Cameron came a cropper on the show when he was forced to admit he did not know the answer to the English translation for Magna Carta.
Before he appears in front of Goswami for the pre-recorded interview, the mayor will visit the Bombay stock exchange, which is Asia's oldest.
During the visit, Mr Johnson is expected to reiterate his desire to see the Indian government continue its efforts to reduce the bureaucracy that restricts some of its private and state-owned companies from listing on overseas exchanges.
He will also confirm that two of India's fastest-growing financial service companies are to establish London-based operations.
He will meet Indian business leaders for breakfast and hold discussions with some of India's wealthiest private investors.