Genoa have a completed a deal for the 24-year-old Spanish winger, understood to be in the region of £4million, pending a medical.
Falque joined Spurs on a season-long loan deal from Juventus three years ago before completing a permanent move the following year, but during his entire time with the club he made only one Premier League appearance.
Falque follows Jake Livermore, Heurelho Gomes and Gylfi Sigurdsson out of White Hart Lane in recent weeks.
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