Genoa have a completed a deal for the 24-year-old Spanish winger, understood to be in the region of £4million, pending a medical.
Falque joined Spurs on a season-long loan deal from Juventus three years ago before completing a permanent move the following year, but during his entire time with the club he made only one Premier League appearance.
Falque follows Jake Livermore, Heurelho Gomes and Gylfi Sigurdsson out of White Hart Lane in recent weeks.
COMMENT RULES: Comments that are judged to be defamatory, abusive or in bad taste are not acceptable and contributors who consistently fall below certain criteria will be permanently blacklisted. The moderator will not enter into debate with individual contributors and the moderator’s decision is final. It is Belfast Telegraph policy to close comments on court cases, tribunals and active legal investigations. We may also close comments on articles which are being targeted for abuse. Problems with commenting? email@example.com