Wigan suffered their eighth successive defeat to slump to the bottom of the Barclays Premier League as goals from Clint Dempsey and Moussa Dembele earned Fulham a 2-0 win at the DW Stadium.
The Latics had enough chances to win the game as Victor Moses and Maynor Figueroa hit the woodwork, but Dempsey in the 41st minute and Dembele four minutes from time were far more clinical.
After repelling some early Fulham attacks, Wigan began to exert some pressure with David Jones having a shot saved by Mark Schwarzer before guiding another past the post.
Approaching the half-hour mark, the home side should have gone ahead. First, Albert Crusat's cross was cleared as far as Ben Watson, whose volley was expertly tipped over by Schwarzer. From the resulting corner, captain Gary Caldwell was unmarked eight yards out but headed over.
There was a heart-in-mouth moment for Schwarzer when he fumbled Moses' low cross-shot but the ball bounced past the post.
After 41 minutes Danny Murphy found Bobby Zamora out on the left and his cross was perfect for Dempsey, whose shot bounced into the net despite the best efforts of Al Habsi. Wigan could have been level at half-time as Moses got a foot to Watson's shot but the ball flew just wide.
In the 54th minute Moses let fly from 25 yards with a stunning volley that bounced off the angle.
Fulham were struggling to get out of their own half but in the 62nd minute Zamora got on the end of a long ball and smashed a volley against the bar.
Schwarzer needed the help of his woodwork again in the 84th minute when Figueroa's swerving shot, which the keeper thought was going wide, bounced off the post.
Wigan's fate was sealed two minutes later as Dembele ran to the edge of the area and placed his shot wide of Al Habsi.