Only Aly Cissokho, Daniel Agger, Jordan Henderson, Iago Aspas and Raheem Sterling remained from the side which beat Hull 2-0 on New Year's Day.
Liverpool manager Brendan Rodgers' son Anton was named on the bench for Oldham, whose side featured just two players who won 3-2 at Boundary Park when the teams met in the fourth round last year.
Brendan Rodgers had this week insisted his son Anton would get no preferential treatment when the two come face to face on Sunday.
Anton, who signed with the Latics in the summer, has featured 13 times for the League One side so far this term.
But father Brendan said he had no intention of going easy on his son.
"In all seriousness, that's the job - but it is also a situation that I will want my players to pay attention to, because the footballing gods sometimes come into it as well," Rodgers senior told several national newspapers.
"With the footballing gods, he could end up getting a goal.
"But not only that, I have to get the team to keep an eye on him because he's a good player.
"He's got quality, he has a great view of the game and he's a real footballer. So I can't skip over it because it's Anton. This is business."
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