Ryan Giggs passed up a glorious opportunity to ease Manchester United nine points clear in the race for the Barclays Premier League title at Newcastle.
The 37-year-old fired wide with the goal at his mercy 21 minutes from time as the Magpies edged closer to safety with a hard-earned point.
Newcastle keeper Tim Krul made fine first-half saves from Javier Hernandez, who was then booked for diving amid loud penalty appeals in injury time, but the home side had their own chances with debutant Stephen Ireland going close with a second-half volley.
Having seen Ireland replace Lovenkrands, Ferguson sent on Valencia in place of Anderson, but it was the Newcastle man who almost made an instant impact when he volleyed just wide from Ameobi's 72nd-minute lay-off.
Ameobi made way for Nile Ranger as the game entered its closing stages with the points still there for the taking.
Nani blasted a 78th-minute effort just wide and Rooney went close from distance two minutes later with United battering away at their hosts.
Giggs might have snatched victory at the death but missed the target once again before a dramatic injury time period.
United appealed vociferously for a penalty after Hernandez went over Simpson's challenge, but the Mexican was instead booked for diving. Rooney then headed wide as the game finished goalless.