Manchester City have confirmed their playmaker David Silva has pulled out of the Spain squad ahead of Tuesday's friendly with Chile after picking up a thigh injury.
A statement on City's official website on Monday afternoon said the problem was not thought to be serious but that Silva would be returning to Manchester to receive treatment and assessment by the club's medical staff.
It remains to be seen whether or not the 27-year-old will be fit for Saturday's Barclays Premier League trip to Stoke.
City confirmed on Friday that their newly-recruited defender Martin Demichelis - only signed on September 1 - is set to be out of action for around six weeks due to a knee injury he sustained in training with them.
They already had defenders nursing injuries, with skipper Vincent Kompany currently sidelined by a groin problem and Micah Richards out with a hamstring complaint.