Hull midfielder Stephen Hunt scored twice in the last 19 minutes as Bolton's defensive deficiencies allowed the Tigers to snatch a point in a 2-2 draw at the Reebok Stadium.
Wanderers looked comfortable after Ivan Klasnic's 20th-minute goal and Kevin Davies' second-half header.
However, Hunt nodded in from close range to spread panic in a defence without a clean sheet all season and the Republic of Ireland international's cross-shot produced the equaliser 12 minutes from time.
Although Bolton have now taken six points from their last four matches, for manager Gary Megson, who again fans called for to be sacked, this was a huge missed opportunity.
Having been out-played for three quarters of the game Hull — who have not won at Bolton since March 1935 — will have been satisfied with a point as they had lost three of their last four league matches and are still to win away this season.
After 20 minutes of relatively nondescript action Bolton took the lead out of nowhere with a typical piece of route one football.
Zat Knight's high ball forward was knocked down by Lee Chung-Yong, under pressure from Andy Dawson, on the edge of the area and Klasnic took one touch before blasting a left-footed shot past Boaz Myhill, who appeared slow to get across his goal.
In the second half, Davies out-muscled Bernard Mendy to nod in a back-header to make it 2-0.
Bolton's hopes of a first clean sheet of the season were dashed in the 71st minute when Hunt headed home for 2-1.
And seven minutes later the same player bagged the equaliser.