The Scot usually manages to raise his game when he needs to but that was certainly not the case on Thursday as he crashed out 6-4 6-3 6-2.
Wawrinka played an inspired match to hand Murray his worst grand slam defeat since losing to the Swiss in the third round in New York three years ago.
Murray had come back from two sets to love down seven times in his career but this did not look like being an eighth.
Wawrinka had got better and better, allowing Murray very few free points on his serve and having an answer for everything off the ground.
The Scot was certainly not helping himself with some very poor errors and it was more of the same in the third game of the third set as a double fault handed Wawrinka another break.
It really was crisis point for Murray and try as hard as he might he just could not find the level of tennis he needed.
He had made more than twice as many unforced errors as winners and it was virtually curtains when Wawrinka drilled another forehand winner to break again for 5-2.
That left the ninth seed serving for the match and a smash brought up a first match point, which he took when Murray netted a forehand after two hours and 15 minutes.
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