Instonians make the short trip to neighbours Belfast Harlequins in the First Trust Senior League tomorrow.
Clem Boyd's men are joint top of Division Three in the All Ireland with seven wins from seven but, after a bruising encounter with Midleton last weekend, the former Ulster prop will juggle his resources for the Deramore Park clash.
"This is a good opportunity for guys pushing to get into the first team to show what they can do.
"There are only two players who started against Midleton in the team this week as we've made 13 changes and we'll probably be up against it," said Boyd.
Full back Ashley Craig and winger Richard Fegan are the only survivors for the 12-try rout of the Cork side.
Neil Simpson comes in at hooker and Ulster U-19s McDowell at lock and Mark Jones at openside flanker get their chance. Former Irish international Niall Malone is moved to outside centre after coming on as a replacement in the previous two games.
Quins suffered a first defeat of the campaign in their last outing, against Dungannon, which reduced their lead at the top of the table to two points. Winger Gavin McLaughlin and loose forward Colin Atkinson are ruled out.
Ulster duo Darren Cave and Paul McKenzie are included in the Quins backline along with Shane Stewart and Willem Slabbert while up front, Niall Conlon, Stuart Philpott and Andy Ward will play.
Queen's travel to Eaton Park (2pm) but can't finalise their side due to an Ireland U-20 training session in Dublin.
Scrum half Ian Porter, lock James Sanford, winger Chris Cochrane and prop Paul Karayiannis may be released.
Third place Malone travel to Banbridge boosted by the availability of Ulster out half Kieran Hallett for the rest of the season.
Back rower Glen Moore and winger John Anderson are ruled out as is lock Sam McDonald until the new year.
Rainey coach Willie Anderson is likely to rotate his squad for the visit of Ards to Hatrick Park.
Scrum half Michael Wilson is definitely ruled out after breaking his collar bone in last week's victory over Waterpark while Neil O'Kane is rested.
Ards have lost all eight league games and coach Mervyn Tweed will also use the next few games to give his squad players an opportunity.
Shane Barr, Colin McClure, Angus Mawhinney, David Armstrong, Kenny Mussett, Cois Beukes and Jay MacKenzie are all in contention. Unavailability rules out full back Peter Connell and prop Tenari Fagilima.
Dungannon should be too strong for City of Derry in the other match.