England coach Stuart Lancaster has included 13 uncapped players in his 42-man squad for the five-match, three-Test summer tour of South Africa.
Chris Robshaw has been confirmed as captain of a squad that also features the return of experienced internationals Danny Care and James Haskell.
Care was excluded from England's RBS 6 Nations campaign on disciplinary grounds, while Haskell was unavailable because he was playing in the southern hemisphere.
The inclusion of Leicester's Tom Youngs as one of four hookers is the most left-field selection, given he has never started a Premiership match in that position. The converted centre has made 12 bench appearances for Leicester and will compete with first choice Dylan Hartley, Lee Mears and the uncapped Harlequin Joe Gray for the hooker's jersey.
Youngs will join his scrum-half brother Ben in the senior England squad for the first time and he is joined by Tigers team-mate Graham Kitchener as a fellow England newcomer. The Wasps pair of wing Christian Wade and flanker Joe Launchbury have been rewarded for their excellent Premiership seasons in a struggling side with a first senior call-up.
Lancaster has drafted in Bath flanker Carl Fearns and Exeter loose forward Tom Johnson after losing Tom Croft and Tom Wood to injury and Callum Clark to suspension.
Despite England's back-row selection issues, there is no return for Nick Easter or Toulon's Steffon Armitage, but Haskell is picked ahead of his return to Wasps from the Otago Highlanders next season.
Harlequins, who finished top of the regular season Premiership table and face Northampton at home in Saturday's semi-final, also provide lock George Robson and centre George Lowe. Saracens full-back Alex Goode and London Irish centre Jonathan Joseph also win their first senior England call-ups.
England forwards: M Botha (Saracens), D Cole (Leicester Tigers), A Corbisiero (London Irish), P Doran-Jones (Northampton Saints), P Dowson (Northampton Saints), C Fearns (Bath Rugby), J Gray (Harlequins), D Hartley (Northampton Saints), J Haskell (Otago Highlanders), T Johnson (Exeter Chiefs), G Kitchener (Leicester Tigers), J Launchbury (London Wasps), J Marler (Harlequins), L Mears (Bath Rugby), B Morgan (Scarlets), M Mullan (Worcester Warriors), T Palmer (Stade Francais), G Parling (Leicester Tigers), C Robshaw (capt, Harlequins), G Robson (Harlequins), M Stevens (Saracens), T Waldrom (Leicester Tigers), T Youngs (Leicester Tigers).
Backs: A Allen (Leicester Tigers), C Ashton (Northampton Saints), B Barritt (Saracens), M Brown (Harlequins), D Care (Harlequins), L Dickson (Northampton Saints), O Farrell (Saracens), T Flood (Leicester Tigers), B Foden (Northampton Saints), A Goode (Saracens), C Hodgson (Saracens), J Joseph (London Irish), G Lowe (Harlequins), U Monye (Harlequins), D Strettle (Saracens), M Tuilagi (Leicester Tigers), J Turner-Hall (Harlequins), C Wade (London Wasps), Ben Youngs (Leicester Tigers).