New Zealand fly-half Dan Carter has withdrawn from the Crusaders side to play the Chiefs in Friday's Super 15 match at Mount Maunganui.
The 29-year-old was due to join Chiefs and All Blacks full-back Mils Muliaina and New Zealand captain and flanker Richie McCaw in making comeback appearances in the game.
However, Carter, who left the field injured in the Crusaders' Twickenham game against the Sharks, suffered a hamstring tightening at training on Wednesday.
His place in the Crusaders side has been taken by Matt Berquist, while Tom Marshall moves onto the reserves bench.
Muliaina suffered fractures to two vertebrae in the week-three match against the Rebels in Hamilton.
Carter was to have marked his 200th first-class game in the match, which will be McCaw's first game of the season after recovering from a stress fracture in his foot suffered during pre-season training.
Coach Todd Blackadder said: "These derby matches are especially important in this season's competition due to the conference format.
"Traditionally they always carry extra spice and it will be a tough, physical match up there.
"I was pleased with what we achieved against the Bulls in Timaru last weekend but we still have plenty to work on and I know the guys are looking forward to doing that."
Kahn Fotuali'i will have his first start of the season at scrum-half while Owen Franks will start at tighthead prop with Ben Franks at loosehead.