A blistering first-half attacking display handed the Reds a comfortable 32-17 bonus-point victory over the Sharks at Suncorp Stadium.
The Sharks slumped to their fifth straight loss with an error-strewn performance, while the Reds played their best rugby of the season to lead 29-3 at the interval.
Reds fly-half Quade Cooper played a part in all of his team's four tries, with Rod Davies claiming a brace and Saia Faingaa and Anthony Faingaa also crossing.
Piet Lindeque scored early in the second half for the Sharks to raise hopes of a tighter contest and Derick Minnie grabbed a late score, but Queensland held on comfortably.
Meanwhile, Aaron Cruden kicked the Chiefs to a tense 22-21 win over the Western Force in Pukekohe.
The Hurricanes claimed a bonus point 39-34 win over the Cheetahs in Bloemfontein and damaged the South African side's play-off hopes as they bounced back from last week's defeat by the Bulls.
The Canes outscored the Cheetahs by four tries to three, although it was a good night for prop Coenie Oosthuisen who scored twice for the home side, while Hurricanes fly-half Beauden Barrett contributed 24 points.
The defeat is a blow to the Cheetahs as the Bulls picked up four points in their bye this week, effectively moving them ahead in the round.
The bonus-point victory lifts the Hurricanes up to eighth in the overall standings, but they are still fourth in the New Zealand conference.