Newcastle Falcons opened their Amlin Challenge Cup campaign with a 27-19 win against European newcomers Lyon at Kingston Park.
First-half tries from second-row Tim Swinson and centre James Fitzpatrick proved the difference to give his side a winning start in Pool Two.
Scrum-half Jordi Pasqualin crossed for the Falcons' third try straight after half-time before Lyon's impressive number eight Nicolas Bontinick responded with Lyon's first European try three minutes later.
Winger Christian Wade scored his second hat-trick of the season as Wasps ran riot in a crushing 47-14 bonus-point victory against Bordeaux-Begles in France. The Aviva Premiership side ran in a total of six tries in front of a home crowd of 16,953 who came to see Bordeaux play their first game in Europe since 2003.
Wasps went in 27-7 ahead at half-time and could even afford to go down to 14-men twice. Lock Ross Filipo and prop Zak Taulafo were sin-binned during the game but centre Dom Waldouck, winger Tom Varndell and replacement scrum-half Nic Berry all crossed for tries.
Sale Sharks will rue their own indiscipline after they had two players sin-binned during a disappointing 26-18 defeat to Brive in their Pool 5 opener.
The former winners, who won the tournament in 2002 and 2005, had two players yellow carded - flanker Dave Seymour and lock Fraser McKenzie - during a ferocious examination. The Sharks did manage a rally when winger Tom Brady and centre Johnny Leota crossed for tries but the visitors were always second best.
Newport Gwent Dragons welcomed back their Wales World Cup stars as they beat Italian minnows I Cavalieri 33-3 in Italy. Dan Lydiate and Toby Faletau led the returning cast as they appeared for the first time since helping Wales to the semi-finals in New Zealand.
All Blacks legend Joe Rokocoko, who left New Zealand to move to France in the summer, scored his first try in European rugby in Bayonne's six-try rout of Italian side Femi-CX Rovigo 43-10.
Agen ran riot as they rattled off a 50-10 victory over Spanish minnows CR La Vila, who won the Spanish title last season and are in their first season of European rugby, in Alicante.