Argentina coach Daniel Hourcade has made four changes to his starting line-up for Saturday's Millennium Stadium clash against Wales.
Santiago Cordero, a 19-year-old wing, takes over from Juan Imhoff after Imhoff went off injured during last weekend's 31-12 loss to England.
Elsewhere, full-back Joaquin Tuculet is preferred to Lucas Amorosino, scrum-half Martin Landajo ousts Tomas Cubelli and lock Manuel Carizza starts instead of Mariano Galarza. Wing Horacio Agulla wins his 50th cap.
Argentina, who have lost their last seven games against all opponents, beat Wales 26-12 in Cardiff last November, but they field just six survivors in their starting line-up from that game.
Wales, meanwhile, have not won an autumn Test since they toppled the Pumas in 2009.
Team: J Tuculet; H Agulla, M Bosch, S Fernandez, S Cordero; N Sanchez, M Landajo; M Ayerza, E Guinazu, M Bustos, M Carizza, P Albacete, P Matera, J F Cabello, J M Leguizamon (capt).
Replacements: S Iglesias Valdez, N Lobo, M Diaz, T Lavanini, L Senatore, T Cubelli, G Ascarate, L Amorosino.