Italy coach Nick Mallett has made four changes to the side that lost their RBS 6 Nations opener against Ireland for Saturday's game against England at Twickenham.
Pablo Canavosio replaces injured Benetton Treviso scrum-half Edoardo Gori, who dislocated his shoulder during the 13-11 defeat to Ireland in Rome last weekend.
Kristopher Burton drops to the bench, with Luciano Orquera taking his place at number 10, while Valerio Bernabo will make his first start in the tournament due to flanker Josh Sole's ankle injury. Carlo Antonio Del Fava will partner Quintin Geldenhuys in the Azzurri's second row, replacing Santiago Dellape who is among the replacements.
Uncapped Fabio Semenzato has been included on the bench.
The good news for Mallett is that captain Sergio Parisse has recovered from a finger injury.
Italy team: L McLean (Benetton Treviso); A Masi (Racing-Metro Paris), G Canale (Clermont-Auvergne), A Sgarbi (Benetton Treviso), Mirco Bergamasco (Racing-Metro Paris); L Orquera (Brive), P Canavosio (MPS Aironi); S Perugini (MPS Aironi), L Ghiraldini (Benetton Treviso), M Castrogiovanni (Leicester Tigers), C Antonio Del Fava (MPS Aironi), Q Geldenhuys (MPS Aironi), V Bernabo (Benetton Treviso), A Zanni (Benetton Treviso), S Parisse (Stade Francais).
Replacements: F Ongaro (MPS Aironi), A Lo Cicero (Racing-Metro Paris), S Dellape (Racing-Metro Paris), R Barbieri (Benetton Treviso), F Semenzato (Benetton Treviso), K Burton (Benetton Treviso), G Garcia (Benetton Treviso).