Toulouse will face defending champions Leinster in a mouth-watering semi-final clash with the prize a place in May's final in Paris.
Toulouse won the all-French Heineken Cup quarter-final yesterday with a crushing 42-16 win over Stade Francais.
Yannick Jauzion, Patricio Albacete and Cedric Heymans scored tries as Guy Noves' men cut loose in the south of France.
But the three-time champions were made to work hard for their success in the opening period after Rodrigo Roncero crossed for Stade. However, the French giants rallied and the turning point came on the stroke of half-time when centre Jauzion burrowed over before Albacete and then Heymans struck late on to put the final nail in the coffin.
Meanwhile, head coach Michael Bradley felt his side's solid first-half display set the tone as Connacht got the better of Bourgoin 23-20 at the Sportsground to qualify for the Amlin Challenge Cup semi-finals.
Bradley said: “We had a very good first half, with just two errors. Bourgoin were able to capitalise on those errors. I thought overall we played the better rugby in the first half.”