Ulster flanker Chris Henry will lead the Ireland Wolfhounds against England Saxons at Sandy Park, Exeter, on Saturday.
Nine capped players have been included in the starting XV, including scrum-half Isaac Boss and hooker Damien Varley, who were both part of the Ireland's World Cup squad.
Simon Zebo, who scored a hat-trick for Munster against Northampton last weekend, has been named on the left wing.
Two of Ireland's most promising centres, Eoin O'Malley and Nevin Spence, have been given a chance to impress in midfield.
Irish Wolfhounds team: G Duffy (Connacht), D Kearney (Leinster), E O'Malley (Leinster), N Spence (Ulster), S Zebo (Munster), I Keatley (Munster), I Boss (Leinster), B Wilkinson (Connacht), D Varley (Munster), S Archer (Munster), D Tuohy (Ulster), M McCarthy (Connacht), J Muldoon (Connacht), C Henry (Ulster, capt), R Ruddock (Leinster).
Replacements: M Sherry (Munster), R Loughney (Connacht), D Toner (Leinster), K McLaughlin (Leinster), T O'Leary (Munster), I Madigan (Leinster), D Hurley (Munster).