Northampton will play Ulster in the quarter-finals of the Heineken Cup after qualifying for the knockout stages as the tournament's top seeds.
Jim Mallinder's Saints were the only team to progress from the group stages with a 100% record and they have been rewarded with a home route to the final.
If Northampton, champions in 2000, can overcome Ulster - in a game set to be played in either Coventry or Milton Keynes - they will host either Perpignan or Jonny Wilkinson's Toulon in a home semi-final.
The Aviva Premiership provided only two Heineken Cup quarter-final qualifiers, with Northampton joined in the last eight by midlands rivals Leicester.
The Tigers, who progressed as one of the leading group runners-up, face new tournament favourites Leinster in a repeat of the 2009 final, set to be staged at Dublin's Aviva Stadium.
The winners of that heavyweight showdown will host a semi-final against either Biarritz or defending champions Toulouse, who meet in the other all-French quarter-final.
Toulouse had the chance to oust Northampton as top seeds and secure a home quarter-final.
But Wasps' 21-16 victory, sealed with a last-gasp try from David Lemi, condemned them to a trip to Biarritz in a repeat of last year's final.
Wasps head down into the Amlin Challenge Cup, where they will face local rivals Harlequins.
Munster and Clermont Auvergne - the other two Heineken Cup drop-outs - tackle Brive and La Rochelle respectively while Stade Francais take on Montpellier.