James Hook will start at fly-half for Wales in Saturday's RBS 6 Nations clash against Scotland at Murrayfield.
Hook moves from full-back, where he started in the 26-19 loss to England last week, and wears Wales' number 10 shirt for the first time since the 2009 Six Nations campaign.
He replaces 96 times-capped Stephen Jones, who drops to the bench after playing a limited part in training this week after taking a bump to his neck during the England game.
Elsewhere, Lee Byrne reclaims the full-back berth and former Wales captain Ryan Jones takes over from shoulder injury victim Andy Powell at number eight.
Wing Morgan Stoddart has been named despite breaking his hand against England, but he faces further fitness checks later this week.
On the bench, a sore hip sidelines scrum-half Dwayne Peel, so there is an opportunity for Scarlets youngster Tavis Knoyle, while uncapped Scarlets flanker Josh Turnbull also features.
Wales, without a win in their last eight Tests, have beaten Scotland at Murrayfield just three times during the past 20 years.
Wales team to play Scotland in the RBS 6 Nations Championship at Murrayfield on Saturday.
Team: L Byrne (Ospreys); M Stoddart (Scarlets), J Roberts (Cardiff Blues), J Davies (Scarlets), S Williams (Ospreys); J Hook (Ospreys), M Phillips (Ospreys); P James (Ospreys), M Rees (Scarlets, capt), C Mitchell (Ospreys), B Davies (Cardiff Blues), A-W Jones (Ospreys), D Lydiate (Newport Gwent Dragons), S Warburton (Cardiff Blues), R Jones (Ospreys).
Replacements: R Hibbard (Ospreys), J Yapp (Cardiff Blues), J Thomas (Ospreys), J Turnbull (Scarlets), T Knoyle (Scarlets), S Jones (Scarlets), R Priestland (Scarlets).