Leicester aim to make it three in a row at Harlequins' Twickenham Stoop fortress
Leicester will aim to maintain their Aviva Premiership play-off push on Friday - but they face a considerable task.
Opponents Harlequins are one of only two sides in this season's Premiership with a 100 per cent home league record, and they are also on the rebound from a defeat against Bath last time out.
Leicester, though, head to London on the back of successive bonus point victories against Gloucester and Bristol, and another maximum haul at the Twickenham Stoop would take them above Bath into fourth place.
"We are happy with the improved performances in the last couple of weeks, but there are still things to grow," Tigers head coach Aaron Mauger said.
"The guys had their feet firmly on the ground in our reviews earlier this week.
"We know there are things we want to tidy up, but also there are some good things coming from what we have been working on during the week."
Centre Peter Betham and back-row forward Lachlan McCaffrey return for Leicester. McCaffrey has sat out the last four games but will pack down alongside back-row colleagues Brendon O'Connor and Mike Fitzgerald and Betham makes his 50th Leicester appearance.
Up-front, there are starts for the likes of Ellis Genge, George McGuigan, Greg Bateman and Harry Wells.
Quins boss John Kingston, meanwhile, has made four changes from the Bath game, with Nick Evans starting at fly-half instead of Ruaridh Jackson and Alofa Alofa taking over from Scotland wing Tim Visser, who is on Six Nations duty this weekend.
Elsewhere, there are call-ups for prop Mark Lambert and lock George Merrick as Quins look to remain in the top-six mix.
Kingston said: "There are seven (Premiership) games to go, and four of those are at home, where our record is terrific.
"We remain unbeaten at home in the Premiership, a record we are looking to continue against a very strong Leicester side.
"Our matches in recent years have been excellent encounters, and I have no doubt it will be another mouthwatering clash as we look to close the gap on the five teams above us in the league."