Glasgow head coach Sean Lineen is seeking the same sharpness and accuracy that have earned them three successive home wins over Leinster as they aim to beat the European champions in Ireland for the first time.
Lineen, who has handed first starts to former Melrose captain Scott Wight, on-loan Ospreys forward Rory Pitman and youngster Finlay Gillies, is looking to strike the first blow as Glasgow take on their Heineken Cup pool opponents in the RaboDirect Pro12.
The former Scotland international, whose side have suffered opening defeats against Ulster and Munster, said: "This is another huge challenge for us, to go to the home of the Heineken Cup holders and look to do something we've never done before, but it's an opportunity the players relish."
He added: "We know we're going to be facing Leinster a good number of times over the course of the season, and although every game is different, it's important we set our stall out and deliver the sort of performance and result we need to kick-start our campaign.
"We know that every error is likely to be punished by a side like Leinster, so it's about being accurate and purposeful in everything we do, and also being sharp enough to capitalise on their mistakes.
"The three times we've beaten them at home in the last couple of years, we've brought all those qualities to the table, so we know it's something we can do if we perform to the same level."