Quins suffer double injury blow
Nick Evans - Harlequins' Amlin Challenge Cup hero last season - and captain Chris Robshaw will both miss a quarter-final showdown against Toulon in France on Friday night.
New Zealander Evans has been ruled out by a foot injury suffered during the victory over Aviva Premiership title rivals Saracens at Wembley last weekend.
Rory Clegg will wear the number 10 shirt at Stade Felix Mayol, replacing Evans, whose last-gasp conversion gave Quins a thrilling win against Stade Francais in the Amlin final almost a year ago.
England skipper Robshaw, meanwhile, aggravated a knock during a team run, so Luke Wallace deputises alongside back-row colleagues Tom Guest and Nick Easter, with lock George Robson leading the team.
Quins rugby director Conor O'Shea highlighted discipline as a key factor for his players ahead of the Toulon clash, admitting "some very dumb penalties" were conceded against Saracens.
England international full-back Mike Brown knows that area must be watertight, especially as points machine Jonny Wilkinson will start for Toulon.
"Discipline has been talked about," Brown said. "It is something we have to improve if we want to go well in the Amlin and stay where we are in the Premiership.
"It's especially true with Wilko this week; that will be a massive test of our discipline. It was a tough game last week, but we always we knew it would be. Saracens aren't the champions of England for no reason.
"They threw everything at us and we managed to hold out, but there is plenty to work on. Our discipline could have let us down."
Toulon will field a galaxy of international stars against Quins, including Wilkinson, centre Matt Giteau, prop Carl Hayman and number eight Joe van Niekerk.