Quins too strong for Exiles
London Irish were dragged deeper into the relegation mire after champions Harlequins ground out a 26-15 victory in front of 82,000 fans at Twickenham.
The Exiles were in touch for 78 minutes but left empty-handed after a late penalty try from Harlequins' dominant pack denied them a losing bonus point.
Harlequins had taken the lead after a scrappy first half with a try from scrum-half Danny Care, and Nick Evans added 16 points with the boot.
Ian Humphreys kicked all the points for London Irish, who are now just one point ahead of the Aviva Premiership's bottom side Sale Sharks.