Glasgow welcome international stand-off Ruaridh Jackson and flanker Richie Vernon back from the Scotland camp following the RBS 6 Nations for their Magners League game against Ulster.
Winger DTH van der Merwe, who signed a new two-year deal this week, has also recovered from a wrist injury ahead of the clash at Firhill.
In the backs, Van der Merwe and Jackson replace Hefin O'Hare and Duncan Weir respectively, who are both dropped to the bench.
In the forwards, Rob Harley moves up into the second row in place of Tom Ryder who is unavailable due to a thigh injury. As a result, James Eddie slots into the blindside role.
Ryan Wilson retains his place at openside while Vernon comes in for Johnnie Beattie.
On the decision to drop Beattie from a solid back-row performance last weekend against Treviso, head coach Sean Lineen explained: "It's more to do with the balance.
"I thought Johnnie had a much-improved game last weekend but players like Ryan Wilson and Rob Harley were outstanding. They are setting the tone at the moment."
Warriors will be looking to follow up last weekend's win over Treviso with victory over play-off chasing Ulster.
Looking back on last week's result Lineen added: "The players were delighted to get the win over Treviso.
"It was a very hard game against big physical men and to get that victory was really encouraging. The team spirit was strong and to score three tries was very good."