The Waratahs made it a club record seven Super Rugby wins in a row with a 34-3 success over the Reds in Brisbane.
The bonus-point success came courtesy of two tries from Kurtley Beale, who also set up another for full-back Jono Lance.
Scrum half Nick Phipps scored the Waratahs' bonus-point try in the 73rd minute, but they had already secured top spot and home semi-final.
Beale stepped up in the absence of Australia full-back Israel Folau, setting up Lance to opener the scoring in the 12th minute and then touching down himself three minutes later.
Both tries were converted by Bernard Foley, who also kicked a first-half penalty.
The Reds cause was not helped by a success of injury blows as Ben Lucas and Ben Tapuai were forced off early on and Mike Harris' first-half penalty was their only score in the match.
Beale extended the visitors lead 15 minutes into the second half, starting off a move with a kick from his own half and, after a slick team move, adding the finishing touch himself under the posts.
Foley converted and did so again after Phipps raced for the corner to score try number four.
He also added another penalty to take his points haul to 14.