England's injury problems continued to mount after wing Christian Wade was ruled out for up to six months with damaged foot ligaments.
"It's devastating news for both the player and the club," Wasps director of rugby Dai Young said.
Wade was due to win his second cap in last month's QBE Internationals, only for a hamstring injury to prevent him from starting against Argentina and New Zealand.
Head coach Stuart Lancaster was keen to give the British and Irish Lion a more prominent role amid the ongoing deterioration of Chris Ashton's form and he was set to start the Six Nations opener against France on February.
The series opens at Eden Park on June 7, continues at Forsyth Barr Stadium seven days later and concludes at Waikato Stadium on June 21.
One midweek match has been scheduled against seven-times Super Rugby champions the Crusaders in Christchurch on June 17.