England international Mathew Tait will make his first appearance of the season on Saturday, admitting: "I am very keen to make up for lost time."
Tait has been recovering from a knee operation, ruling him out of Sale Sharks' opening five Aviva Premiership games and the Amlin Challenge Cup opener against Cetransa El Salvador last Friday. But the England Saxons squad member returns in Sharks' encounter against Italian side Petrarca at Stadio Plebiscito.
"The knee operation was to clean out some debris," said Tait. "I feel great now and can't wait to get a good run of games under my belt. I am very keen to make up for lost time."
Sale scored 15 tries in posting a club-record 97-11 European win against Cetransa, but Petrarca should prove tougher opponents, especially as French sides Bayonne and Bourgoin feature among their notable scalps on home soil during previous campaigns.
"We must be disciplined," said Sale head coach Mike Brewer.
"The big mistake teams make when they travel to Italy is that they automatically think the winning bonus point is guaranteed. Our first objective is to win the game - once that is achieved, we can start to look for a bonus."
Brewer, meanwhile, has left out scrum-half Dwayne Peel as a precautionary measure after he suffered a groin strain training with Wales, meaning another opportunity for 21-year-old Will Cliff.