Leicester could set a new Aviva Premiership record if they continue their blistering domestic form at the expense of fierce rivals Northampton on Saturday.
Tigers will become the first club in Premiership history to register five successive bonus-point victories by achieving a maximum haul at Franklin's Gardens.
"It's a big game," said Saints rugby director Jim Mallinder. "Obviously, Leicester are our local rivals, but we know that we've got three games to go in the regular season and we want to win all three to give us a chance of a home semi-final."
He added: "We have not been talking about what has gone before. We've trained hard and prepared for what is going to come at us on Saturday.
"Leicester are physical up front and love the set-piece, but they like to play a bit too and get on the front foot."
If Northampton slip up - and they have only lost once at home in the Premiership this season - then Exeter could overtake them by beating Worcester at Sixways.
That would then set the scene for a crunch clash between the Chiefs and Saints in Devon on Sunday week.
"The reality, as we've said to the players, is that we are now at the business end of the season and we are still fighting for things," Exeter head coach Rob Baxter said.
"A week ago we were in Paris fighting in a quarter-final of a European cup competition, and now we are fighting to see if we can establish ourselves either in the Heineken Cup or that top four.
"Saturday is another great opportunity for us, but the key is not to look too far ahead of ourselves and instead concentrate fully on Worcester."