Butch James, Jannie du Plessis and Flip van der Merwe are all doubts for South Africa ahead of this week's final Tri-Nations encounter against Australia in Bloemfontein.
The trio sat out training on Monday, but the nature of their injuries are yet to be revealed after they underwent scans earlier in the day.
However, reports suggest that Bath fly-half James, who has had several knee problems in the past, is the most serious of the concerns.
He came off the bench for the last 15 minutes of the game at Loftus Versfeld and put in at least three key tackles to help the world champions claim a 44-31 win over the Wallabies - their first of the 2010 Tri-Nations.
Addressing a press conference in the Free State capital, coach Peter de Villiers did not divulge too much on their injuries.
Instead, he hailed the change in attitude amongst his players after they ended their four-match losing streak.
"The win has changed the mood in the camp and the guys need to build on this from a mental and physical point of view," he said.
"This is where a positive attitude towards the match will be very important.
"The Wallabies are world class and we will have to have the right attitude to beat them again, especially on attack."