Saracens prop Mako Vunipola will make his first England start in Sunday's RBS 6 Nations clash with Italy as one of five changes made by head coach Stuart Lancaster from the 23-13 victory over France.
Vunipola, who won his first seven Test caps as a high-impact replacement, replaces Joe Marler at loosehead, with Tom Youngs taking over at hooker from Dylan Hartley. Wasps flanker James Haskell returns on the blindside in place of Courtney Lawes and England go into the game with a new half-back combination.
Toby Flood takes over at fly-half from Owen Farrell, who is recovering from a strained thigh muscle suffered against France, and Danny Care gets his chance at scrum-half in place of Ben Youngs.
With Farrell not being risked, Gloucester fly-half Freddie Burns is on the bench and eyeing a second cap, having made a successful debut off the bench in December's win against New Zealand.
Joining Burns among the replacements is Tom Croft, the Leicester flanker, who returns to the England fold 11 months after a broken neck almost left him paralysed. He made his comeback for Leicester on January 4 and rejoined the England squad after being given medical clearance to play every week.
Lancaster said: "We were very happy with the way we finished the France game. The impact the replacements made shows that we have competition for places across the board and we have had to make some tight calls.
"Italy will be highly motivated for this game and we will have to perform for the full 80 minutes. I am sure those starting will seize their chance and the bench will also have a significant part to play as the game goes on.
"The support at Twickenham for the Scotland and France games was superb and I am sure the atmosphere will be fantastic again for our final home match of the championship."
England team: A Goode (Saracens); C Ashton (Saracens), M Tuilagi (Leicester), B Barritt (Saracens), M Brown (Harlequins); T Flood (Leicester), D Care (Harlequins); M Vunipola (Saracens), T Youngs (Leicester), D Cole (Leicester), J Launchbury (Wasps), G Parling (Leicester), J Haskell (Wasps), C Robshaw (Harlequins, capt), T Wood (Northampton).
Replacements: D Hartley (Northampton), D Wilson (Bath), J Marler (Harlequins), C Lawes (Northampton), T Croft (Leicester), B Youngs (Leicester), F Burns (Gloucester), B Twelvetrees (Gloucester).