Shane Williams weaved his magic with a spectacular try in a 27-16 win over London Irish and gave the Ospreys' Heineken Cup campaign lift-off.
Brilliant Williams' scintillating solo score helped inflict only a second defeat of the season on Aviva Premiership leaders Irish.
And the visitors could have few complaints as Williams' fellow Lions wing Tommy Bowe claimed an early touchdown before fly-half Dan Biggar kicked four penalties.
Centre James Hook, who moved to 10 when Biggar went off injured early in the second period, added a conversion and penalty, while Irish mustered a Sailosi Tagicakibau interception try, plus 11 points from Ryan Lamb.
The Ospreys, Heineken quarter-finalists in each of the past three seasons, delivered one of their finest European performances.
They were hungry from the start, and the win has put them firmly in quarter-final contention from Pool Three, a punishing group that also includes Irish heavyweights Munster and Jonny Wilkinson's Toulon.
Irish will also undoubtedly feature at the qualifying business end in January, but it was a sobering night for them at the Liberty Stadium as Ospreys - and Williams in particular - produced some champagne rugby.