Wasps boss David Young wants his players to build "a fortress mentality" at Adams Park this season.
Young's men will run out on home soil for the first time this season when they host Aviva Premiership opponents London Irish on Saturday.
They have collected three bonus points so far in going down to defeat against Harlequins and Bath, although the quality of rugby Wasps showed on both occasions suggests an encouraging campaign ahead. "If you want to do well in this competition you win the majority of your home games. That will put you halfway up the league," Young said.
"If you can build that fortress mentality then it puts you in a strong position. We've shown glimpses over the last two games of how good we can be without putting in an 80-minute performance. We've made mistakes that I'm confident we can put right.
"A win at home would give the fans something to smile about and give the players confidence, taking a little bit of a monkey off our back. Everyone is looking for that first win as early as they can in the season."
Reigning champions Quins will be expected to make it three wins out of three when Sale Sharks visit the Twickenham Stoop, with their fellow early pace-setters Saracens and Leicester meeting at Wembley and Worcester entertaining Gloucester.
Bath and Northampton, meanwhile, will put their 100% Premiership records on the line in Friday's clash at the Recreation Ground.
Saints head to the west country following victories over Gloucester and Exeter, while Bath defeated Worcester and Wasps in their opening two Premiership games.
"Bath will be a big challenge," Northampton rugby director Jim Mallinder said. "They have started the season very well. They came from a long way behind and held their nerve to win at Sixways, while against Wasps last weekend they put together some dangerous attacking moves.
"The Rec is always a tough place to play. It is a place where the fans are right on top of you and where it can be intimidating for visiting teams, so it is up to us as to how we respond."