Ireland wing Simon Zebo will miss the remainder of the RBS 6 Nations after breaking a bone in his foot in the 12-6 defeat by England at the Aviva Stadium.
Zebo will undergo an operation on Monday to repair the damage incurred in the 10th minute of a brutal Test in Dublin and has been ruled out for up to 10 weeks.
The prognosis on Jonathan Sexton's hamstring injury was less grave with coach Declan Kidney estimating a two-week lay-off for the Leinster fly-half, who was replaced by Ronan O'Gara after half an hour.
Flanker Sean O'Brien (tight hamstring), lock Mike McCarthy (knee ligament strain), centre Brian O'Driscoll (twisted ankle) and lock Donnacha Ryan (back) also sustained injuries, but have yet to be ruled out against Scotland in two weeks time.
"Simon will have surgery. Jonny will have a scan either later tonight (Sunday) or tomorrow," Kidney said.
"It looks like a couple of weeks for Jonny, but it would be wrong to try and second guess the outcome. We'll know more by Tuesday.
"It's been an attritional couple of games and we had a few injuries leading into the tournament, but that's the way it goes."