Accountancy firm EY are set to create 486 jobs in Belfast.
A new business unit in Belfast will advise clients outside Northern Ireland and the highly-paid posts, which include auditing, will be filled over the next four years.
Stormont's ministerial Executive said it would contribute £19m in direct salaries a year once all roles are established.
Mike McKerr, managing partner at EY Ireland, said: "We are delighted to bring this investment to Belfast which will further enhance our current service offering to clients.
"As a global company with a presence in more than 150 countries, we continually evaluate the best locations for expansion to ensure maximum productivity and growth.
"We have been working closely with Invest Northern Ireland for some time on this project and their support and advice has been instrumental in EY's decision to locate this project in Belfast."
The firm already employs almost 1,500 people in Northern Ireland and the Republic of Ireland.
Government jobs creation agency Invest NI is offering almost £3m in aid to encourage the company to pledge 486 new jobs.
Mr McKerr added: "The roles will comprise of a mobile and static workforce, providing assurance and advisory services to EY's UKI domestic and international client base.
"This announcement will help the firm to achieve its twin targets of increasing its market share and delivering a quality, cost-effective service to its customer base."
Democratic Unionist First Minister Peter Robinson said it was positive news for Belfast.
"Alternative global locations were considered by the company so securing these high quality jobs has been a real coup," he said.
"This announcement sends an unambiguous message to international investors to have confidence in Northern Ireland as a competitive location from which to grow their business."