The historic Belfast Telegraph headquarters on Royal Avenue in Belfast is on the market today.
Declan Flynn, managing director of commercial property agents Lisney, appointed to sell the property last month, said interest in the building had already been "very strong".
Mr Flynn said: "The majority of interest so far has come from UK or Republic of Ireland-based developers or hoteliers."
He said location was a major selling point. "The main factor with this property is its proximity to Ulster University, the city centre, and ease of access to the main motorway network."
Lisney has said the building could be adapted to uses including a hotel, which would make use of its listed frontage.
The remainder of the one acre site could be used for student or residential homes, or serviced apartments.
In today's Belfast Telegraph, former Editor Ed Curran writes about the history of the building, which dates back to 1870.
Mr Curran writes that the building "reflected the growth of Belfast as the industrial revolution turned the city into one of the fastest growing in Europe".