Around 800 new jobs are being created in Co Fermanagh - the largest single announcement outside of Belfast in 12 years.
The international customer service firm took over management of the Liberty Insurance contact centre earlier this year in Co Fermanagh, securing the existing 200 jobs at the site.
The new jobs are said to be worth £12m to the Northern Ireland economy, and will average just under £15,000 in salaries.
It plans to create the new jobs by 2018.
Just four months ago, Liberty had warned that it would cut 270 jobs across Ireland, 20 of which were in Fermanagh.
The agreement between Teleperformance and Liberty Insurance meant that more than 200 jobs were saved.
Since then, with the help of Invest NI, Teleperformance has announced plans to expand and will carry out work for other contracts at the site.
Finance Minister Arlene Foster said: "This major investment is great news for Northern Ireland and I am delighted to have played a part in the journey that has brought Teleperformance to Fermanagh.
"I have taken an active interest in the company’s involvement in Northern Ireland and have been privileged to engage with them over the last number of years. Securing this further investment for Fermanagh marks another tremendous milestone which I am proud to be a part of.
“A reinvestment by this international company is a significant endorsement for Northern Ireland and what we have to offer companies as a place to do business.
“The new centre will deliver a number of benefits to the local economy, not least the creation of 800 new jobs and the generation of £12m per annum in salaries.
“The job opportunities created will not only benefit people in Enniskillen but also those in the surrounding areas. There will be a wide variety of roles appealing to those looking to develop their career, and those looking to return to work. There will also be opportunities for young people, who will benefit greatly from training and skills development as they begin their working career."
Invest NI has offered £2.5million of support towards the project. The Department of Employment and Learning has offered £249,500 of support through Assured Skills for pre-employment training for 100 people.
The company currently runs five UK offices, three of which are in Northern Ireland. Aside from the Enniskillen centre, the firm's two other call centres are based in Newry and Bangor and employ a combined 2,000 people.
Teleperformance's UK clients include HM Passport Service, NHS Blood Transplant, Renault UK, Natwest Bank and Sainsbury's.
Teleperformance is part of the Teleperformance Group, which has a workforce of over 182,000 across 270 contact centres in 62 countries, the largest network of contact centres in the world.
This week, France's Teleperformance also announced it will open a contact centre in Lithuania creating over 2,000 jobs.
It manages programs in 75 languages and dialects on behalf of major international companies operating in a wide variety of industries.
Contracts the company works on include customer care, technical support and debt collection programmes.
Tom Elliott, Ulster Unionist MP for Fermanagh & South Tyrone, welcomed the news.
Mr Elliott said: "This is very welcome news for Enniskillen and the wider Fermanagh & South Tyrone area. I am pleased that Teleperformance are planning to create 800 jobs by 2018. There have been a number of ups and downs in terms of jobs in Enniskillen over the past couple of years and I hope that these particular jobs will be sustainable on a long term basis.
"The people of Enniskillen and the wider Fermanagh & South Tyrone area have the abilities and the skills to push Northern Ireland forward if they are given the opportunity. I hope that this is one of many investments in the local economy."