The future of around 1,600 UK jobs has been thrown into doubt after the owner of Andrex toilet tissue and Huggies nappies unveiled a swingeing cost-cutting drive.
Kimberly-Clark plans to slash between 5,000 and 5,500 roles from its 43,000-strong global workforce, the equivalent of 12% to 13% of total staff.
The Texas-based personal care giant has three UK manufacturing sites - in Barrow-in-Furness, Flint and Northfleet - as well as offices in Reigate, West Malling and Brighton.
The move will hit "all of the company's business segments and organisations in each major geography", with 10 manufacturing plants earmarked for sale or closure.
The group is eyeing annual cost savings of $500m (£357m) to $550m (£393m) by 2021.
Chairman and chief executive Thomas Falk said the restructuring plan will put the group on track to reach its long-term growth targets.
He said: "This is the biggest restructuring we have undertaken since the introduction of our Global Business Plan in 2003, and it will make our company leaner, stronger and faster.
"The changes we are making will improve our underlying profitability, provide more flexibility to invest in growth opportunities and help us compete even more effectively."
Kimberly-Clark also owns household names such as Pull-Ups and Kleenex.