The north west makes a "compelling" investment proposition thanks to a cross-border location with a foothold in the EU and the UK, potential US investors have been told.
Delegates from the north west of Northern Ireland and Co Donegal travelled to Philadelphia and Boston with representatives from Derry City and Strabane District Council and Donegal County Council as part of a trade and investment mission.
They met industry specialists, foreign direct investment executives and venture capitalists during the week-long visit.
A spokesman said the councils outlined the attractions of the region as "a talented and educated workforce... the superb quality of life and the supportive business environment".
Meetings were also held with Boston mayor Marty Walsh and Philadelphia's mayor Senator Jim Kenney.
Michaela Boyle, mayor of Derry City and Strabane District Council, said the event had raised the profile of the north west as an investment location.
"Access to the investment community and engaging with them on a one-to-one basis allowed us to showcase what the north west region has to offer," she said.
"Being able to share with them our vision and ambition as well as the practical support and assistance available to businesses in the region is vital if we are to stimulate growth and investment.
"There is real value in having face to face engagements if we are serious about building meaningful connections and relationships that will benefit the region."
Businesses from both council areas also joined the mission, including male skincare brand Humanity Cosmetics.
Company director Christopher Reid said that the visit had been a "fantastic opportunity" to build on his own research.