Brendan Fraser and Denis O'Hare are to star in a stage version of the comedy Elling.
Dennis will play the compulsive title character and Brendan will play the enthusiastic Kjell.
It will be Brendan's Broadway debut, though the actor has performed on the stage in London.
Producers say Jennifer Coolidge and Richard Easton will co-star.
The play, which will arrive on Broadway in November, will run at the Ethel Barrymore Theatre on November 2 and open on November 21.
Adapted for the English stage by Simon Bent, Elling is based on the Norwegian novels of Ingvar Ambjornsen.
The books, about a pair of roommates, were previously made into the 2001 Oscar-nominated movie by the same name.
The production premiered in London.