Life is tough for PR doyenne Edina Monsoon (Jennifer Saunders). Her client list has thinned to Lulu and Emma Bunton and she continues to clash with strait-laced daughter Saffy (Julia Sawalha), who struggles to protect her 13-year-old daughter Lola (Indeyarna Donaldson-Holness) from Edina's negative influence.
And then Edina's lucrative autobiography deal collapses when an editor (Mark Gatiss) points out she's nothing to say. "I put Sting in a rainforest, I put Bono behind yellow glasses," splutters Edina. "I gave celebrities Aids."
Thankfully, best friend Patsy Stone (Lumley) is in the media eye and her magazine is sponsoring a lavish party for designer Huki Muki (Janette Tough). Kate Moss, who is between publicists, is due to attend the soiree and Edina vows to add the supermodel to her dwindling client roster before arch rival Claudia Bing (Celia Imrie).
This hare-brained scheme ends in tragedy and Kate Moss' demise is blamed on Edina and Patsy. "Manslaughter charges might be brought," confirms a detective (Robert Webb), who is dating Saffy. When ditzy secretary Bubble (Jane Horrocks) vanishes too, Edina and Patsy flee to the Cote d'Azur to snag wealthy husbands.
"Living well is the best revenge," affirms Patsy with a lipstick-smeared grin.