Elusive music producer KDA is on course to become number one on Friday with his track, Turn The Music Louder (Rumble) featuring Tinie Tempah and Katy B.
The dance track has over 7,000 more combined sales than its nearest competitor , One Direction's Perfect.
If it succeeds in keeping ahead of the competition then KDA and Katy B will score their first number one, although it will be Tinie Tempah's seventh.
London DJ KDA's identity is not known, but he has attracted attention for his remixes of Kylie Minogue, Chvrches and London Grammar tunes.
One Direction are new in at number two with their second single from upcoming album Made In The A.M.
Be Right There, a collaboration between Diplo and Canadian DJ and producer Sleepy Tom, is set to be this week's highest climber, up 88 places to number three mid-week, while The Weeknd's The Hills is at number four.
Jamie Lawson, the first artist signed to Ed Sheeran's label Gingerbread Man Records, is set to complete the top 5 with his track Wasn't Expecting That and to bag pole position in the album charts.
The 39-year-old's eponymous album has double the sales of second place contender Demi Lovato. Her latest collection Confident could be her highest charting UK album yet, after 2013's offering peaked at number 10.
Rounding off the all-new Top 5 are John Newman's second album Revolve at number three, English rockers Nothing But Thieves' self-titled release at four, and Peter Andre's 10th album Come Fly With Me landing in fifth.