Annie Lennox will be honoured with a prestigious O2 Silver Clef Award at this year's Nordoff Robbins Awards Lunch.
The prize, given to a British artist in recognition of their contribution to UK music, will reward the former Eurythmics singer's lifelong commitment to music and her global musical achievements.
One of the most successful female artists in UK music history with record sales exceeding 80 million, singer-songwriter Annie enjoyed chart-topping hits and collected several Brit and Grammy awards with the band.
She went on to forge a solo career and her debut album Diva, released in 1992, sold more than eight million copies. Her most recent album A Christmas Cornucopia, released in November 2010, reached the UK Top 20.
Annie said she was "thrilled and honoured" to receive the award from the charity which uses music to transform the lives of people of all ages in the UK.
"I've supported Nordoff Robbins over the years and I'm a firm believer in their work and the healing power of music," she added.
The charity's chairman David Munns said it was "proud and honoured" to be presenting the songstress with the prestigious award.
"As a prize that recognises the contribution a British artiste has made to music, I can think of no more worthy recipient. As an outstanding musician and philanthropist, Annie's influence has been felt globally," he said.
Last year's Silver Clef winners included Muse, JLS and Dizzee Rascal. The awards have honoured The Who, Elton John, Pink Floyd, Paul McCartney, Sting, Take That, and Kylie Minogue in previous years.
The awards will take place on July 1 at the London Hilton in Park Lane.