Katy Perry, Justin Bieber and Kesha are set to take the stage at the 38th annual American Music Awards.
All three, who are multiple nominees and up for artist of the year, along with Lady Gaga and Eminem, will make their AMAs debuts next month, producers said.
Justin, 16, who is nominated for four awards, said he's "extremely humbled and honoured" to be part of the show, which honours the most popular albums and artists.
"As a small-town kid from Canada, I never imagined that I would be nominated for AMAs, let alone be performing on the show," he said without hinting at what song he plans to perform.
Kesha and newlwed Katy are up for three gongs each. Eminem and Lady Antebellum lead nominees with five apiece.
Kesha said she's excited for her "first big American awards-show performance" and humbled to be nominated for artist of the year with some of her idols.
"To have my name nominated alongside them really solidifies the impact I've had on American pop culture and pop music the past year," she said. "I'm really honoured and definitely going to cover America in glitter."
She said she'll perform a medley that includes her new single, We Are Who We Are.
Katy, who married comedian Russell Brand last week, didn't reveal her performance plans.
Other artists slated to perform at the November 21 show include Christina Aguilera, Bon Jovi, Usher and Pink.