Michael Jackson was so heavily drugged in the hours before his death that he would have been incapable of self-administering the massive dose of propofol that killed him, a medical expert testified at the trial of Jackson's doctor.
Dr Steven Shafer, who presented a number of possible scenarios for Jackson's overdose, said one posed by Dr Conrad Murray's defence - that the star gave himself the powerful anaesthetic - is "crazy".
"He can't give himself an injection if he's asleep," Dr Shafer told jurors.
Dr Shafer took the jury through a virtual chemistry class with diagrams and formulas projected on a large screen.
He indicated the residue of drugs found during Jackson's autopsy suggested Murray gave his patient much larger doses of sedatives than he told police.
He also said Jackson would have been extremely groggy from the drugs administered by IV throughout the night.
Murray told police he was away from Jackson for just two minutes - a period during which the defence says the singer could have grabbed a syringe and given himself additional propofol.
"People don't just wake up from anaesthesia hell bent to pick up a syringe and pump it into the IV," Dr Shafer said, reminding the jury that the procedure was complicated. "It's a crazy scenario."
His opinions set up an expected clash with the views of his colleague, Dr Paul White, who was waiting to testify for the defence.
Murray has pleaded not guilty to involuntary manslaughter.