Only 10 housemates remain in the Celebrity Big Brother house after Kristina Rihanoff was evicted and David Bowie's ex wife, Angie, walked out.
The 66-year-old former model departed the show due to illness - she is the third celebrity to quit and pack her bags.
After demanding an exit from the show on Monday's programme, in the diary room she yelled and insisted: "Get me a car and let me be gone, if you want to be cheap get me an Uber," and "I want to leave now! Get me my stuff! Give me my stuff! Now!"
Spending the night in the spare bedroom, the next day before quitting Bowie saw the doctor, spruced herself up, and when she rejoined the others told them she had a temperature of 103F (39C).
In the diary room Bowie said on her departure: "I am so sorry that I got sick and so very very sorry to have to leave the show. Just now they said the sweetest thing 'stay here we will look after you don't leave'.
"Bye bye everyone - see you."
A Channel 5 spokesman said: "After being unwell for a few days, Angie Bowie has decided to leave the Celebrity Big Brother house."
Bowie had originally decided to stay in the house following the news that her former husband had died of cancer.
On Monday American producer David Gest also quit due to medical reasons - he joined Kim Kardashian's good friend Jonathan Cheban, who left last week, citing its "bad vibe".
Dancer Kristina, joined Nancy Dell'Olio and Winston McKenzie in being voted off the show by viewers.
The pregnant Strictly Come Dancing star was visibly happy at being booted out of this year's programme, saying "yes" as the result was announced.
Talking after her eviction the 38-year-old Russian said: "I am over the moon; it was all I have been praying for in the last few days.
"The arguments became so vicious - it is not my cup of tea at all. I am really happy to leave; it is the right moment because it was getting very difficult for me."
Danniella Westbrook, John Partridge and Tiffany Pollard, who were also facing eviction, were all saved by the public.