The actor is the founder of the Just Keep Livin' charitable foundation.
Matthew McConaughey has teamed up with bosses at skincare company Kiehl's to raise awareness about autism.
The Dallas Buyers Club star worked with designers at the company to create packaging for a limited edition Ultra Facial Cream, and he also appears in a video for the campaign, asking viewers to share it to raise funds.
For every post, company bosses will donate $1 (£.77) to Autism Speaks until they hit a goal of $200,000 (£154,000).
The 47-year-old first got involved with the autism campaign because he has had personal experience with children who have the developmental disorder through his Just Keep Livin' charitable foundation.
"Autism affects an estimated 70 million people worldwide, and many of the students enrolled in my Just Keep Livin' after school programs are on the autism spectrum," he tells People magazine. "I've witnessed firsthand the effects of autism, not only on the child, but on their families as well."
Matthew reveals he was inspired to launch the foundation after his son Levi was born in 2008 and his good work continues with Autism Speaks.
"I knew I wanted to find a way to help kids, in particular high school kids who are really at a pivotal phase in their lives," he adds. "Our work with Just Keep Livin' is dedicated to empower youth and provide them with the tools they need to make healthy choices and lead active and productive lives."
And he makes sure to pass his values down to his three children with wife Camila Alves.
"As a family, we are fortunate to give back through the year," he says. "Camila, the kids, and I deliver food every Thanksgiving in Austin, we often visit the Just Keep Livin' programme in various schools and we are fortunate enough to travel the world when I work, which provides the kids an education in culture so they don't really look at shapes, sizes, and colours as being different."