Rylan Clark-Neal thanked This Morning viewers after he and husband Dan Neal became the first gay couple to present ITV's flagship series.
A relieved Clark-Neal said: "We've done it," at the end of the live two-hour show on Friday.
The broadcast went smoothly, with no mishaps or bloopers of note on-air.
Clark-Neal and his husband stood in for the absent Eamonn Holmes and Ruth Langsford, the regular anchor husband and wife team.
Topics covered on the milestone instalment included the Spice Girls' reunion, policing in America and an interview with The X Factor's Chloe Jasmine and Stevi Ritchie.
Guest Marina Fogle, wife of adventurer Ben Fogle, also explained why she is in favour of a "marriage MOT".
Formerly a contestant on The X Factor, since winning Celebrity Big Brother in 2013, Clark-Neal has forged a successful career as a presenter.
Neal, an ex-detective constable, admitted to nerves and stumbled over his words on occasion.
He was on more solid ground talking about policing in the US with former Metropolitan police marksman Tony Long.
The face of Big Brother's Channel 5 sister show Big Brother's Bit On The Side, Clark-Neal also presents the showbiz segment on This Morning.
As the popular show got under way, Clark-Neal joked: "I'm not going to lie, I'm just worried about my own job!"
The couple showcased their relationship to viewers with moments of in-jokes and banter.
Following a 2012 clip of Clark-Neal on The X Factor singing a Spice Girls medley, the Big Brother presenter linked it to the leadership contest between Tory MPs Theresa May and Andrea Leadsom.
"Speaking of a bit of girl power, Britain is about to get its second ever female prime minister," Clark-Neal said.
Neal mentioned May's status as the favourite and added: "There might be a little surprise. We didn't think Brexit was going to happen, did we?"
Clark-Neal replied: "Life is getting more and more like The X Factor by the day. Everything is just turning into a public vote."
Ahead of the broadcast, the London-born star told This Morning's Holly Willoughby and Phillip Schofield of his reluctance to make a fuss about the July 8 show.
"We're just two people coming in to present the show and we're really, really happy we've got the opportunity," he said.
Clark-Neal met his husband when the former policeman was a Big Brother housemate in 2013. They married two years later.
Celebrity viewers of Friday's show who posted messages of support on Twitter included EastEnders star Danniella Westbrook.